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Vol.13 No.4

Datum izdavanja: Prosinac 2004.

 

SADRŽAJ:

ANALYSIS OF PROGNOSTIC FACTORS AND OF TYPE OF TREATMENT IN PATIENTS WITH ENDOMETRIAL CANCER IN THE FIRST FIGO STAGE (Vol.13 No.4, str.149-149)

ANALIZA PROGNOSTIČKIH ČIMBENIKA I NAČINA LIJEČENJA U BOLESNICA S RAKOM ENDOMETRIJA U PRVOM FIGO STADIJU (Vol.13 No.4, str.149-154)

Autori:

Herman Haller, Maja Kraševic, Teodora Stanković, Drazen Kovač, Ružica Karnjuš-Begonja, Stanislav Rupčić, Ozren Mamula, Darko Mozetič, Miroslav Stamatović, Miljenko Manestar, Alenka Brnčić-Fisher, Nebojša Sindik

Izvorni znanstveni članak

Sažetak
Objective. To analyze the effect of histopathologic characteristics and usefullness of therapy mode in FIGO stage I endometrial cancer patients. Methods. Retrospectively were analyzed 219 endometrial cancer patients with hysterectomy, salpingoophorectomy and pelvic lymphadenectomy (peritoneal cytology and nodes negative). Patients characteristics include age, myometrial invasion, FIGO substages, histologic type, tumor grade, type of hysterectomy and adjuvant radio¬therapy. The mean age was 59 years (SD 8, Min. 39, Max. 75 years). Follow up ranges from 1 to 180 months (median 68). In 85 patients radical hysterectomies were performed and 45 patients received adjuvant radiotherapy. Results. Five year disease related survival was 92,8%. There is no significant difference among analyzed histopathologic patient’s characteristics related to five years survival. In 82 (37.3%) patients out of 219 were found cumulative negative prognostic factors (high risk patients) including non-endometrioid histology, poor tumor differentiation and/or outer half of miometrial invasion. There is no difference in survival between low (91,2%) and high risk patients (93,9%). Radical hysterectomy as well as adjuvant radiotherapy has no advantage in five year survival. Conclusion. This retrospective study has not identified histopathologic prognostic significant characteristics in FIGO stage I endometrial cancer patients. The use of radical hysterectomy and/or adjuvant radiotherapy has not better five years survival and should be reevaluated.

Ključne riječi
endometrial cancer; FIGO; adjuvant therapy; lymphadenectomy; myometrial invasion; tumor differentiation; histology


POBOLJŠANA STOPA OPLODNJE I POROD INJICIRANJEM POTPUNO NEPOKRETNIH SPERMATOZOIDA ODABRANIH HIPOOSMOTSKIM TESTOM NABREKNUĆA U CITOPLAZMU JAJNE STANICE (Vol.13 No.4, str.155-155)

IMPROVED FERTILIZATION RATE AND A BIRTH AFTER INTRACYTOPLASMIC SPERM INJECTION OF TOTALLY IMMOTILE SPERM, PRESELECTED BY THE HYPO-OSMOTIC SWELLING TEST (Vol.13 No.4, str.155-158)

Autori:

Mojca Čižek Sajko, Borut Kovačič, Veljko Vlaisavljević

Izvorni znanstveni članak

Sažetak
Oplodnja izvan tijela može se upotrijebiti u liječenju neplodnosti uzrokovane potpunom nepokretljivošću spermatozoida. Naravno, vjerojatnost za začeće nakon oplodnje spermatozoidom koji je slučajno odabran za injiciranje u citoplazmu jajne stanice (ICSI), prilično je nesigurna. U parova, u kojih u ejakulatu nalazimo samo nepokretne spermatozoide, hipoosmotski test nabreknuća repa spermatozoida hypo-osmotic swelling (HOS) test, upotrebljen je za selekciju vitalnih spermatozoida za ICSI. Materijal i metode. Potpuni izostanak pokretljivosti spermatozoida dijagnosticiran je kao glavni uzrok neplodnosti u 4 para. Među njima, kod dvojice muškaraca ustanovljen je poseban oblik potpune nepokretljivosti uzrokovan defektom ostatka repa. Od 10 hormonima stimuliranih ICSI ciklusa, u 6 ciklusa su spermatozoidi za ICSI izabirani nasumce bez HOS testa. U 4 pacijenta oprani spermatozoidi su inkubirani u hipoosmotskoj otopini i samo HOS pozitivni spermatozoidi (spermatozoidi s nabreklim repom), upotrebljeni su za ICSI. Rezultati. Od 6 ICSI ciklusa bez učinjene selekcije spermatozoida HOS testom, potpuni izostanak oplodnje zabilježen je u 3 ciklusa. U preostala 3 ciklusa samo 20,7% (6/29) jajnih stanica je oplođeno. U sva 4 ICSI ciklusa u kojima je pred njihovim injiciranjem za odabir spermatozoida upotrijebljen HOS test, stvoreni su zameci primjereni za prijenos u maternicu. Zabilježena je stopa oplodnje¬ jajnih stanica od 81,8% (18/22), a nakon prijenosa zametka zabilježena je implantacija dva zametka i rođenje jednog zdravog djeteta. Zaključak. U slučajevima potpune nepokretljivosti spermatozoida, čak i u pacijenata gdje je uzrok neplod¬nosti nedostatak struktura repa spermatozoida, možemo očekivati dobru stopu oplodnje i trudnoće nakon selekcije spermatozoida HOS testom.

Ključne riječi
potpuna astenozoospermija; ICSI; HOS test; trudnoća

 


 

REPRODUCTIVE RISKS IN CARRIERS OF REARRANGEMENT OF CHROMOSOME STRUCTURE (Vol.13 No.4, str.159-159)

REPRODUKCIJSKI RIZICI NOSITELJA STRUKTURNIH KROMOSOMSKIH RAZMJEŠTANJA (Vol.13 No.3, str.159-164)

Autori:

Selim Kolgeci, Shefqet Lulaj, Mehmedali Azemi

Izvorni znanstveni članak

Sažetak
Objective. To estabilish which forms with balanced translocation carry the highest risk for the birth of new unbalanced descendants. Methods. Chromosomes have been obtained from lymphocytes of the peripheral blood according¬ to the modified method of Moorehead and al., whereas the identification of chromosomes was done thorough the method of ribbons-G (Seabright). Results. Cytogenetic research of 5 families is presented. In four families, where the silent carriers were family relatives, the same translocation 6;17 was found. Out of them three women were silent carriers of balanced translocations: 46, XX, t (6;17) (p22;p13), and a male person with a karyotype: 46, XY, t (6;17) (p22;p13). The production ability of these silent carriers with balanced translocations is reduced due to spontaneous miscarriages and the delivery of children with malformations. Children with congenital malformations are carriers of partial trisomia 6p and monosomy 17p, that has occured due to the 2:2 disjunction and the adjacent balanced translocation 6;17. Balanced translocation 8;12 with segments of high translocation: 46, XY, t (8;12) (p12;q12) were found in one family. The wife of these examined patient had 7 habitual and one delivered baby. Conclusion. It is concluded that the highest risk for the delivery of babies with malformations have the silent carriers of balanced translocations with segments of short translocation.

Ključne riječi
balanced translocations; chromosome anomalies; spontaneous miscarriages

 


DYSTHANASIA AND NEWBORNS WITH SEVERE MALFORMATIONS (Vol.13 No.4, str.165-165)

DISTANAZIJA I NOVOROĐENČAD S TEŠKIM MALFORMACIJAMA (Vol.13 No.4, str.165-170)

Autori:

Aleksandra Frković

Pregledni rad

Sažetak
The introduction of new bioethical terms such as orthothanasia, misthanasia and dysthanasia testify to the dynamic development of bioethics. The term dysthanasia means excessive prolongation of the patient’s agony, suffering and death. Life can be prolonged by the administration of different drugs and application of sophisticated technology, when there is no hope for healing. Such a useless treatment brings no or less benefit to the patient and increases the suffering not only of the patient, but of his family as well. Sometimes it is very difficult to make a prognosis for the newborn’s life, in spite of the assessment of his present state and damage by a very sophisticated machines. If the therapy is not effective, the paliative care is necessary, as in any other age. According to some FIGO directions newborns with severe malformations have the right to die with dignity without any useless medical intervention, when the physicians and the parents consider it in their best interest. The Declaration of Barcelona on the Rights of Mother and Newborn states that if the fetus is born with anomalies which are incompatible with life »futile therapeutic measures should not be applied to the newly born«. The wish to make any newborn survive has become the topic of numerous bioethical discussions. These discussions can help the physicians to decide whether a medical treatment is useful or it is dysthanasia.

Ključne riječi
dysthanasia; newborns; severe malformations


SAVJETOVANJE MINISTARSTVA ZDRAVSTVA RH O PERINATALNOJ SKRBI KAO ZDRAVSTVENOM PROBLEMU HRVATSKE - ZAKLJUČAK (Vol.13 No.4, str.173-174)

SAVJETOVANJE MINISTARSTVA ZDRAVSTVA RH O PERINATALNOJ SKRBI KAO ZDRAVSTVENOM PROBLEMU HRVATSKE - ZAKLJUČAK (Vol.13 No.4, str.173-174)

Autori:

Ante Dražančić, Zlata Beer, Vlatka Mejaški-Bošnjak, Ivica Kostović, Boris Filipović-Grčić

Vijest


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